Almost every week, a patient in Hudson, Stow, Twinsburg or Aurora tells me some version of the same story: “I’m tired all the time, I’m gaining weight, my sleep is off, and I think it’s my hormones.”
Sometimes it is. Sometimes it’s the thyroid, low iron, low vitamin D or something else entirely. The only way to know is to test. That’s why every hormone plan at Serene starts with blood work, and why I don’t prescribe hormone therapy based on symptoms alone.
Why labs come first
1. To confirm the diagnosis
Symptoms of low hormones are real, but they aren’t specific. The American Urological Association guideline, for example, says low testosterone should be diagnosed only after two early-morning total testosterone tests on separate days, using 300 ng/dL as a reasonable cutoff, and only when symptoms are present too.
2. To rule out look-alikes
An underactive thyroid, anemia, low iron, low vitamin B12 and low vitamin D can all cause fatigue, brain fog, weight changes and low mood. A good baseline panel checks for them, so we treat the right problem.
3. To set a safe starting point
Before any treatment, I want to know how your kidneys and liver are working, what your blood count looks like and, for men, where your PSA stands. Those numbers become the reference point for everything that follows.
What a baseline hormone panel checks
As a Biote Certified Provider, we use Biote’s lab panels, processed by Labcorp. A baseline panel typically includes:
- Sex hormones: estradiol, total and free testosterone, and SHBG (the protein that binds them)
- Pituitary signals: FSH for women; LH and prolactin in the men’s expanded panel
- Thyroid: TSH, free T3, free T4 and TPO antibodies
- Vitamins and iron: vitamin B12, vitamin D and, in the women’s expanded panel, ferritin
- General health: a complete blood count (CBC) and a comprehensive metabolic panel (CMP)
- Prostate: PSA for men
You can see every panel and what each test tells us on our hormone optimization page.
Why testing continues during treatment
Starting therapy is not the finish line. Follow-up labs show how your body responded and keep treatment safe.
- Blood count. Testosterone can raise red blood cell levels. The Endocrine Society recommends checking hematocrit before treatment, at 3–6 months and then yearly, and pausing therapy if it rises above 54%.
- Pellets are no exception. In a study comparing gels, injections and pellets in men, about 35% of men on pellets developed a hematocrit of 50% or higher during follow-up (versus about 67% on injections and 13% on gels). The authors concluded that blood counts should be monitored regularly.
- Prostate. For many men 55 to 69, the Endocrine Society recommends a PSA check 3–12 months after starting testosterone, then routine screening.
- Women. An international consensus statement recommends a baseline testosterone level before treatment, a repeat level 3–6 weeks after starting, and periodic checks to make sure levels don’t run higher than a woman’s normal range.
Follow-up numbers also help us fine-tune your next dose, so treatment matches how you feel and what your labs show.
How it works at Serene in Hudson
- Consultation. We review your symptoms, history and goals, and choose the right panel.
- Blood draw. Your labs are processed by Labcorp. Lab fees are reviewed with you before anything is ordered.
- Results review. I go over your numbers with you and explain what they mean, whether or not hormone therapy is the right answer.
- Follow-up panels. If you start treatment, we repeat a shorter panel to track your response and safety.
Frequently asked questions
Can I start hormone therapy without labs?
Not at Serene. Labs confirm whether hormones are the cause of your symptoms, rule out other conditions and give us a safe starting point.
How often will I need blood work?
A follow-up panel is drawn after treatment, and then at intervals your physician sets. For testosterone therapy, guidelines recommend checking blood counts at 3–6 months and then yearly.
Is one testosterone test enough?
For men, guidelines recommend two early-morning tests on separate days before diagnosing low testosterone, because levels vary during the day.
What if my labs are normal?
That’s useful information too. It points us toward other causes of your symptoms, and I’ll tell you honestly if hormone therapy isn’t the right fit.
Start with answers
Serene Med Spa is at 50 W Streetsboro St, Suite 2, Hudson, OH, serving Hudson, Stow, Twinsburg, Aurora, Solon, Cuyahoga Falls and Akron. Book a hormone consultation and start with your numbers.
References: Mulhall JP, et al. Evaluation and Management of Testosterone Deficiency: AUA Guideline. J Urol. 2018. · Bhasin S, et al. Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018. · Pastuszak AW, et al. Comparison of the Effects of Testosterone Gels, Injections, and Pellets on Serum Hormones, Erythrocytosis, Lipids, and PSA. Sex Med. 2015. · Davis SR, et al. Global Consensus Position Statement on the Use of Testosterone Therapy for Women. J Clin Endocrinol Metab. 2019.
This article is for general information only and is not medical advice. Lab testing and hormone therapy are provided only after consultation and evaluation by a licensed provider. Individual results vary.